Associations with early-life socio-economic position in adult DNA methylation
نویسندگان
چکیده
منابع مشابه
Associations with early-life socio-economic position in adult DNA methylation.
BACKGROUND Disadvantaged socio-economic position (SEP) in childhood is associated with increased adult mortality and morbidity. We aimed to establish whether childhood SEP was associated with differential methylation of adult DNA. METHODS Forty adult males from the 1958 British Birth Cohort Study were selected from SEP extremes in both early childhood and mid-adulthood. We performed genome-wi...
متن کاملThe association of childhood socio-economic position and psychological distress in adulthood: is it mediated by adult socio-economic position?
There is substantial evidence that lower socio-economic position (SEP) is associated with poorer mental health outcomes. However, uncertainties exist about the origins of socioeconomic gradients in mental health problems and the relative contributions of both childhood and adult SEP. In this study we assess the association of childhood SEP with psychological distress in adulthood and investigat...
متن کاملEarly life socio-economic position and later alcohol use: birth cohort study
AIMS To investigate associations between socio-economic position in early life and later alcohol use and problem use among male and female adolescents. DESIGN Birth cohort study. SETTING South West England. PARTICIPANTS A total of 2711 girls and 2379 boys with one or more measures of alcohol use or problem use at age 15 years. MEASUREMENTS Exposure measures were highest parental social ...
متن کاملAssociations Between Early Life Stress and Gene Methylation in Children
Children exposed to extreme stress are at heightened risk for developing mental and physical disorders. However, little is known about mechanisms underlying these associations in humans. An emerging insight is that children's social environments change gene expression, which contributes to biological vulnerabilities for behavioral problems. Epigenetic changes in the glucocorticoid receptor gene...
متن کاملDNA methylation, behavior and early life adversity.
The impact of early physical and social environments on life-long phenotypes is well known. Moreover, we have documented evidence for gene-environment interactions where identical gene variants are associated with different phenotypes that are dependent on early life adversity. What are the mechanisms that embed these early life experiences in the genome? DNA methylation is an enzymatically-cat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2011
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyr147